ProxiCor

Aziyo Biologics

ProxiCor is an extracellular matrix (ECM) derived from porcine small intestine submucosa (SIS) used for the reconstruction of the pericardium and as an intracardiac patch or pledget for tissue repair.

The Natural Choice for Pericardial Reconstruction. Reconstruction of the pericardium using ProxiCor for Pericardial Closure enables surgeons to re-establish this normal anatomic structure.¹ ² Absence of the pericardial barrier after cardiac surgery often leads to scarring and the formation of adhesions between the heart and sternum, which can impair normal heart function, as well as disruption of normal intra-cardiac pressures.² ³ An extracellular matrix derived from porcine small intestine submucosa (SIS ECM) encourages healthy healing and tissue regeneration.⁴ Pericardial reconstruction with ProxiCor makes recovery less eventful with fewer post-operative complications.³

Reconstruct the Pericardium with ProxiCor PC:

• Consists of natural material, non-crosslinked bioscaffold ⁵

• Modulates the biologic healing response and reduces inflammation ⁴

• More resistant to infection than synthetic material ⁶

• Resists calcification ⁷

• Remodels into vascularized, site-specific tissue ³ ⁴

• Fewer post-op complications ³

• Bioscaffold patch enables hemostasis and minimizes bleeding at suture lines ¹

• Offers customization of material to be shaped to fit anatomy ⁸

References:

¹ Sundermann S, et al. Thorac Cardiovasc Surg. 2014 Feb;62(1):76-9.

² Stelly M, et al. Ann Thorac Surg. 2013 Nov;96(5):e127-9.

³ Rego A, et al. J Cardiothorac Surg. 2019 Mar 15;14(1):61.

⁴ Piterina A, et al. Int J Mol Sci. 2009 Nov 20;10(10):4375-417.

⁵ Data on file at Aziyo Biologics, Inc.

⁶ Brennan E, et al. Tissue Eng. 2006;12(10):2949-55.

⁷ Haney L, et al. Ann Thorac Surg. 2021 Aug 8:S0003-4975(21)01384-9.

⁸ Aziyo Biologics, Inc., ProxiCor for Pericardial Closure Instructions for Use.

Click on link for more information: https://www.aziyo.com/products/cardiac-vascular- surgery/proxicor-pc/

The Natural Choice for Intracardiac Repair. In cases such as atrial or ventricular septal defect repair, ProxiCor CTR can effectively repair a defect and generate new, healthy tissue in lieu of using synthetic patches or performing interventional procedures with devices such as nitinol plugs. ¹ ² An extracellular matrix derived from porcine small intestine submucosa (SIS ECM), ProxiCor CTR encourages healthy healing by reducing inflammation and promoting tissue regeneration. ³ Unlike synthetic alternatives, SIS ECM has demonstrated a reduced foreign body reaction and post-op inflammation. ³

Repair Intracardiac Defects with ProxiCor CTR:

• Consists of natural material, non-crosslinked bioscaffold ⁴

• Modulates the biologic healing response and reduces inflammation ³

• Resists calcification ⁵

• More resistant to infection than synthetic material ⁶

• Repairs defects and restores natural cardiac tissue ¹ ²

• Remodels into vascularized, site-specific tissue ¹ ³

• Bioscaffold patch enables hemostasis and minimizes bleeding at suture lines ⁷

• Takes only 1-2 minutes of preparation in sterile saline ⁸

• Offers customization of material to be shaped to fit anatomy ⁸

Ideal Uses for ProxiCor for Cardiac Tissue Repair:

• ASD Repair

• VSD Repair

• Aortic Root Enlargement

• Left Ventricular Aneurysm Repair

• Sinus of Valsalva Aneurysm

• Repair of Cardiac Tumors

• Endocarditis

• Use as a Pledget

• Suture-Line Buttressing

References:

¹ Ferng A, et al. Ann Thorac Surg. 2017 Sep;104(3):e239-e241.

² Scholl F, et al. World J Pediatr Congenit Heart Surg. 2010 Apr;1(1):132-6.

³ Piterina A, et al. Int J Mol Sci. 2009 Nov 20;10(10):4375-417.

⁴ Data on file at Aziyo Biologics, Inc.

⁵ Haney L, et al. Ann Thorac Surg. 2021 Aug 8:S0003-4975(21)01384-9.

⁶ Brennan E, et al. Tissue Eng. 2006;12(10):2945-55.

⁷ Sundermann S, et al. Interact Cardiovasc Thorac Surg. 2015 Jan;20(1):10-4.

⁸ Aziyo Biologics, Inc., ProxiCor for Cardiac Tissue Repair Instructions for Use.

Click on link for more information: https://www.aziyo.com/products/cardiac-vascular- surgery/proxicor-ctr/

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